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ok i'm new but here's one I've learned. Sniper solo in the middle lane. Bloodseeker in the river between top and middle. Sniper draws the creeps towards his middle tower forcing the target into the river to get farm. Sniper at level 6 uses assassinate as soon as that hits bloodseeker jumps the target. Should be an easy kill early game.
Only goes wrong with bad timing or poor positioning. It will work with nearly any range/jungler combo.
One thing to keep in mind is that lane comp is very subjective. What works for me may not work for you, and vice versa.
One thing that stays consistent, however, is skill setup. A good lane for early kills will have a LOT of early game CC. Good examples include Skeleton King and Chaos Knight, since both have a wicked nasty stun, that also deals pretty good damage. But that doesn't limit it to just stuns. Slows can also be a very effective way to take out a lane early on. Heroes such as Lich and Undying can fit that bill, what with their AoE slows.
One thing to always keep in mind is this: Who is the carry and who is the support? If there's a Crystal Maiden and a Luna in the same lane, CM should get 0 Last Hits, since she should be focused on harassing the enemy heroes, as well as denying LH for them. Know your role, and play it effectively.
Personally, I'm a huge fan of a Doom/Earthshaker lane, though it's very iffy, seeing as how they're both melee heroes. Another good one is Riki/anyone with a good stun. Disruptor/Kunkka is a **** move, no matter how you slice it.
When you have the time, read through the 'Learn' tab. See the different Heroes, know their spells and how they work, and start thinking of how that hero can be countered.
There are a lot of heroes who can contribute to a kill after level 6, usually who are classified as a ganker will work on a lane too.
Before level 6 I think Pudge + a stun works well, also Bane with his ability to take out one of the two heroes on the lane while you finish the other one is useful too.
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