This guide is for you, i think it might help.
It is important that in Dota 2 you set the controls so that they feel right for YOU. Some people hate moving the map with their mouse (me being one of them). Some people cant use QWER for the skills, and find it easier to use different bindings. if you feel unconfortable with the default bindings, invent your own to suit you. this guide will tell you what you need to consider, and will also show you my bindings, which you can use too, if it feels easier.
Overall it is important your keys suit you and you only. if they work, then they work, if you fail at them, then they don't work. if your stuck, try my bindings. Good luck :)